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PRADAL Alexandre
CNRS Research Associate

Sorbonne Université,
4 Place Jussieu, 75252 Paris cedex 5

Couloir 32-42 4ème étage

Office 414
Tel: 33(0)1 44 27 41 14



Research interests:

Organometallic catalysis, domino reactions, C-H activation, biomass valorization.

Current research:

  • Functionalization of aliphatic aldehydes and ketones by direct β-palladation.
  • Domino processes involving Pd-catalyzed transformations (dehydrogenation, Tsuji-Trost allylation…).
  • New allylic C-H activation reactions
  • C(sp3)-H funtionalization by hydride abstraction (oxammonium salts, tritylium cations)
  • Valorization of biomass-derived monomers (coming from lignin depolymerization, terpenes)
  • Total synthesis of natural products.

Recent Results:

  • Oxoammonium-mediated allylsilane-ether coupling reaction.

Scientific background:

  • Since october 2016: Chargé de Recherche CNRS (Research associate) at Sorbonne Université - UPMC (Paris VI - IPCM UMR 8232) in Prof. Giovanni Poli’s team.
  • March-Sept. 2016: Postdoctoral position at the URCOM Laboratory in the Université du Havre (Le Havre, France) under the supervision of Dr. Catherine Taillier and Prof. Vincent Dalla.
    Topic: Gold catalysis for N-acyliminium and ynamide chemistry. Collaboration with Prof. Gwilherm Evano (ULB, Brussels).
  • Feb.-Oct. 2015: Postdoctoral position at the Pfizer Organic Synthesis Laboratory in the University of Nottingham (Nottingham, UK) under the supervision of Prof. Christopher J. Moody.
    Topic: Total synthesis of diazonamide A.
  • April 2013-Sept. 2014: Postdoctoral position at the Laboratoire de Chimie Organique in the Université Libre de Bruxelles (Brussels, Belgium) under the supervision of Prof. Gwilherm Evano.
    Topic: Copper-catalyzed coupling reactions.
  • 2009-2012: PhD in organic chemistry at the Laboratoire Charles Friedel (UMR 7223) at Chimie ParisTech (Paris, France) under the supervision of Drs Véronique Michelet and Patrick Toullec.
    Topic: Asymmetric gold- and platinum-catalyzed cycloisomerization reactions and gold-catalyzed direct C-H acyloxylation of hindered arenes.

Selected papers:

  1. “Room Temperature Metal-Free Electrophilic 5-Endo Selective Iodocarbocyclisation of 1,5-enynes”. Pradal, A.; Nasr, A.; Toullec, P. Y.; Michelet, V. Org. Lett. 2010, 12, 5222.
  2. “Gold-Catalyzed Oxidative Acyloxylation of Arenes”. Pradal, A.; Toullec, P. Y.; Michelet, V. Org. Lett. 2011, 13, 6086.
  3. “Combinatorial Approach to Chiral Trisligated Carbophilic Platinum Complexes: Application to Asymmetric Catalysis”. Pradal, A.; Gladiali, S.; Michelet, V.; Toullec, P. Y. Chem. Eur. J. 2014, 20, 7128.
  4. “A Vinylic Rosenmund-von Braun Reaction: Practical Synthesis of Acrylonitriles”. Pradal, A.; Evano, G. Chem. Commun. 2014, 50, 11907.
  5. “Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement”. David, N.; Pasceri, R.; Kitson, R. R. A.; Pradal, A.; Moody, C. J., Chem. Eur. J. 2016, 22, 10867.

Full list of publications: