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LESAGE Denis
Research Engineer

Sorbonne Université,
4 Place Jussieu, 75252 Paris cedex 5

Couloir 42-43 4ème étage
Team CSOB

Tel:33(0)1 44 27 36 81

mail:



Research interests:

  • Mass spectrometry

Current research:

  • Gas phase reactivity – Study of reaction mechanisms
  • Unimolecular ion decomposition – RRKM-QET modeling

Recent results:

  • Study of reaction intermediates


Figure 1: RRKM-QET Modeling for phenylethyne incorporation on Palladium (II)-Phosphinous acid complex (PA).


Figure 2: Comparison of the decomposition of Platinium(II) and Palladium(II) Phosphinito Phosphinous Acid complexes.

  • Internal energy calibration of an ESI source


Figure 3: Mean internal energy versus cone voltage values for molecules of different sizes.


Figure 4: Internal energy distributions versus cone voltage values for an ion of 420 degrees of freedom.

Scientific career:

  • Thesis of analytical chemistry, Paris VI University, directed by the Pr. Jean-Claude Tabet.
  • DEA of analytical chemistry, INSTN, Saclay Paris VI University.

Selected publications:

  1. RRKM modeling of collision activated reaction/collision induced dissociation experiments: Energy profile determination for phenylethyne incorporation on palladium (II)–phosphinous acid complex, D. Lesage, A. Memboeuf, Y. Gimbert, Y., J.-C. Tabet, Int. J. Mass Spectrom., 319 (2012) 31.
  2. Do Platinum(II) and Palladium(II) Phosphinito Phosphinous Acids Generate the Same Type of Reactive Intermediate in Alkyne Coordination? A Gas-Phase Study with Phenylethyne and Propargyl Acetate, M. Karanik, D. Lesage, Y. Gimbert, N. Nava, S. Humbel, L. Giordano, G. Buono, J.-C. Tabet, Organometallics, 30 (2011) 4814.
  3. Internal energy distribution of peptides in electrospray ionization: ESI and collision-induced dissociation spectra calculation, A. Pak, D. Lesage, Y. Gimbert, K. Vékey, J.-C. Tabet, J. Mass Spectrom., 43 (2008) 447.