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THORIMBERT Serge
Professor

Sorbonne Université,
4 Place Jussieu, 75252 Paris cedex 5

Couloir 33-43 4ème étage. case 229
Team Chembio

Tel:33(0)1 44 27 30 84

mail:



Research interests :

Organic Synthesis, Fluorophores, Homogeneous and Heterogeneous Catalysis, New Hybrid Materials…

Current research:

  • Preparation of Aromatic Heterocycles
  • Reactivity of Methylcoumalate ; Gentiopicroside Synthesis
  • Application of organometalic Compounds in Biology.

Recent results :

  • Hybrid Polyoxomatalates.1-3

  • Around Methyl Coumalate.4-6

  • New heterocycles.7-9

  • Organometalic Compounds.10-11

Scientific career

  • 1989-1993:Ph.D. thesis under the supervision of Prof. J.-P. Genêt. (at ENSCP)
    Catalytic enantioselective synthesis of amino acids (Pd, Ru...).
  • 1993-1994 : Post-doctoral position at the MPI fur Kohlenforschung (Mulheim) with Prof. W.F. Maier.
    Use of the sol-gel method for the preparation of new catalysts for selective oxidation.
  • 1995-2010: Associate Professor at the University P. et M. Curie. in collaboration with prof M. Malacria.
    Asymmetric synthesis, Catalysis. Preparation of hybrid polyoxometalates.
  • 1998-1999 : Academic Visitor, Imperial College of Science (London) with Prof. D. Craig.
    Preparation and reactivity of tetrahydropyridines.
  • Since 2010 : Full professor of Organic Chemistry at UPMC. ChemBio Team
    • Preparation and Functionalisation of Heterocyclic Compounds ; Toward new fluorophores.
    • Organometallic anticancer probes
    • Bio-based compounds: Use of methyl coumalate
    • Hybrid Polyoxometalates From Catalysis to biosensors.

Selected publications:

List (up to date) at : http://www.researcherid.com/rid/C-3699-2009 or https://scholar.google.fr/citations?user=Nl_X5ikAAAAJ&hl=en

  1. Chiral Dawson-type hybrid polyoxometalate catalyze enantioselective Diels-Alder reaction. W.-J. Xuan, C. Botuha, B. Hasenknopf,* S. Thorimbert* Chem. Eur. J. 2015, 21, 16512-16516. (link)
  2. Hot Paper: PCR incorporation of polyoxometalate modified deoxynucleotide triphosphates and their application in molecular electrochemical sensing of Yersinia Pestis. M. Ortiz, A. M. Debela, M. Svodobova, S. Thorimbert, D. Lesage, R. B. Cole, B. Hasenknopf, C. K. O´Sullivan Chem. Eur. J. 2017, 23, 10597-10603 (link)
  3. Electrochemical primer extension based on polyoxometalate electroactive labels for multiplexed detection of single nucleotide polymorphisms N. Chahin, L. Uribe, A. Mehdi, S. Thorimbert, B. Hasenknopf, M. Ortiz, I. Katakis, C. O’Sullivan Biosensors and Bioelectronics 2018, under press (link)
  4. Regio- and stereo-selective preparation of α,γ-unsaturated carboxylic acids by one-pot sequential double 1,6-addition of Grignard reagents onto methylcoumalate. K. Plevovà, L. Chang, E. Martin, Q. Llopis, L. Dechoux,* S. Thorimbert* Adv. Synth. Catal. 2016, 358, 3293-3297. (link)
  5. Preparation of substituted 2H-Pyrans via a cascade reaction from methyl coumalate and activated methylene nucleophiles. L. Chang, K. Plevová, S. Thorimbert,* L. Dechoux* J. Org. Chem. 2017, 82, 5499–5505. (link)
  6. A solvent-free, base-catalyzed domino reaction towards trifluoromethylated benzenes from bio-based methyl coumalate. L. Chang, N. Klipfel, L. Dechoux,* S. Thorimbert* Green Chem., 2018, 20, 1491-1498. (link)
  7. Access to pyridyl-substituted 1,3,5-Triazines from 4H-pyrido[1,3]oxazin-4-ones via a cyclocondensation process. L. Le Falher, O. Ben Ayad, O. Ziyaret, A. Mamontov, C. Botuha,* S. Thorimbert,* F. Slowinski* J. Org. Chem. 2014, 79, 6579-6589. (link)
  8. Preparation of halogen-containing 4H-pyrido[e][1,3]oxazin-4-ones and their transformations into 2-hydroxypyridinyl-substituted 1,2,4-oxadiazoles and 1,2,4-triazoles. L. Le Falher, O. Ben Ayad, O. Ziyaret, C. Botuha,* S. Thorimbert,* F. Slowinski* Eur. J. Org. Chem. 2015, 17, 3830-3840. (link)
  9. Chemoselective access to π-conjugated heterocycles via Stille and Sonogashira reactions on 2-substituted 4H-pyrido[e][1,3]oxazin-4-ones. L. Le Falher, A. Mumtaz, A. Nina Diogo, S. Thorimbert,* C. Botuha* Eur. J. Org. Chem. 2017, 827-832. (link)
  10. Very Important Paper: Supramolecular anchoring of NCN-pincer palladium complexes into a β-barrel protein host. Molecular docking and reactivity insigh. L. Pocquet, N. Vologdin, G. F. Mangiatordi, I. Ciofini, O. Nicolotti, S. Thorimbert,* M. Salmain* Eur. J. Inorg. Chem. 2017, 3622–3634 (link)
  11. Cover paper: Synthesis, photophysical properties and living cell imaging of theranostic half-sandwich iridium – BODIPY dyads. J. M. Zimbron, K. Passador, B. Gatin-Fraudet, C.-M. Bachelet, D. Plazuk, L.-M. Chamoreau, C. Botuha, S. Thorimbert,* M. Salmain* Organometallics, 2017, 36, 3435-3442. (link)