Institut Parisien de Chimie Moléculaire

Also staff member of Ecole Nationale Supérieure de Chimie de Paris (ENSCP-Chimie-ParisTech>, member of PSL)
https://www.researchgate.net/profile/Pascal-Pigeon
https://www.linkedin.com/in/pascal-pigeon-44127b68
https://www.webofscience.com/wos/author/record/965887
http://orcid.org/0000-0001-5374-5346
http://scholar.google.fr/citations?user=JA7gN3sAAAAJ (citations : >3200, h-index: 34)
h-index: 33 - Citations (WOS) : >2750 - publications: 90
Patents: 3

Research interests :

Medicinal organometallic chemistry, Organometallic and organic synthesis.

Current research :

• Synthesis of organométallic compounds (ferrocene).
• Synthesis of molecules having anticancer activity, antibacterial effect or having activity against plant diseases.
• Synthesis of molecules bearing organométallic and heterocyclic moieties: chemical reactivity and anticancer activity.

Recent results:

• Improvement of anticancer activity of Ferrocidiphenols by modification of the carbonated chain :
• by a hydroxyl (Angewandte Chemie International Edition, 2015, 54 (35), 10230-10233 DOI: 10.1002/anie.201503048 (PDF Hal) - Journal of Organometallic Chemistry, 2017, 829, 108-115 DOI: 10.1016/j.jorganchem.2016.09.005 (PDF Hal) - Chemical Science, 2018, 9, 70-78 DOI: 10.1039/C7SC04213B (PDF Hal)
• by a heterocycle (J. Med. Chem., 2017, 60 (20), 8358–8368 DOI: 10.1021/acs.jmedchem.7b00743 (PDF Hal) - Angew. Chem. Int. Ed. 2019, 58, 8421-8425 DOI: 10.1002/anie.201902456 (PDF Hal) - Molecules 2022, 27(14), 4549 DOI: 10.3390/molecules27144549 - European Journal of Medicinal Chemistry 2022, 114202 DOI: 10.1016/j.ejmech.2022.114202 (PDF Hal
• Patent (n° EP13306480 - WO2015063201A1) with Pr G. Jaouen and Dr. Siden Top.
• Collaborations for biologic tests (Institut du Cerveau-Paris : Int. J. Mol. Sci., 2021, 19, 10404 DOI 10.3390/ijms221910404) and formulations (with Université de Nancy : Int. J. Pharm. 2015, 491, 323-334 DOI: 10.1016/j.ijpharm.2015.06.043 - J. Pharm. Pharmacol. 2018, 70, 11, 1474-1484 DOI: 10.1111/jphp.12998 (PDF Hal) - Molecules, 2022, 14, 4651 DOI: 10.3390/molecules27144651), with Université d’Angers (Nanoscale, 2018, 10, 13485-13501 DOI: 10.1039/C8NR02132E (PDF Hal) - J. Phys. Chem. Lett., 2019, 10, 21, 6613-6620 DOI: 10.1021/acs.jpclett.9b01493 (PDF Hal) - Int. J. Pharm., 2022, 122164 DOI: 10.1016/j.ijpharm.2022.122164 (PDF Hal). Study of fluorescence restored by blocking quenche by oxidation, with ENS
  Paris (Molecules, 2022, 19, 6690 DOI: 10.3390/molecules27196690).

Special event:

Article in the IPCM newsletter:
Pascal Pigeon (Chembio Team) inaugurates the « Recherche Data Gouv Sorbonne Université space »
A first dataset was deposited on the institutional space by Pascal Pigeon (IPCM). It is described with complete documentation (rich metadata and a very detailed Readme file). This dataset is linked to an article under review and a source code deposited on HAL and archived on Software Heritage.
See the short article here

Scientific career:

• Studies in chemistry at University of Rouen
• Ph. D. thesis (chemistry) under the supervision of Pr. Bernard Decroix (University of Le Havre 1996)
• Assistant-engineer at ENSCP (Paris 1999-2001)
• Research ingeener at ENSCP (Paris 2001-today). Linked to IPCM (Paris 2014-today)

Journal Covers:

front cover	Inside cover	front cover	Inside cover

Selected publications:

List (up to date) at : http://scholar.google.fr/citations?user=JA7gN3sAAAAJ

1. Anne Vessières, Siden Top, Pascal Pigeon, Elizabeth Hillard, Leila Boubeker, Daniela Spera, and Gérard Jaouen. Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. Generation of anti-proliferative effects in vivo. J. Med. Chem., 48, 3937-3940 (2005).
2. Yong Wang, Marie-Aude Richard, Siden Top, Patrick M. Dansette, Pascal Pigeon, Anne Vessières, Daniel Mansuy, Gérard Jaouen
   Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols and Oxidative Transformation
   Angew. Chem. Int. Ed. 2016, 55, 10431-10434.
3. Yong Wang, Pascal Pigeon, Siden Top, Michael J. McGlinchey, Gérard Jaouen
   Organometallic Antitumor Compounds : Ferrocifens as Precursors to Quinone Methides.
   Angew. Chem. Int. Ed. 2015, 54, 10230-10233.
4. Pascal Pigeon, Yong Wang, Siden Top, Feten Najlaoui, Maria Garcia Alvarez, Jérôme Bignon, Michael McGlinchey, Gerard Jaouen. A new series of succinimido-ferrociphenols and related heterocyclic species induce strong antiproliferative effects, especially against ovarian cancer cells resistant to cisplatin. J. Med. Chem. 2017, 60, 8358-8368.
5. Yong Wang, Pascal Pigeon, Siden Top, Juan García, Claire Troufflard, Ilaria Ciofini, Michael McGlinchey, Gerard Jaouen Atypical lone pair-π interaction with quinone methides in a series of imido-ferrociphenol anticancer drug candidates. Angew. Chem. Int. Ed. 2019, 58, 8421-8425.
6. Pascal Pigeon, Marie Gaschard, Mohamed Othman, Michèle Salmain, Gérard Jaouen. α-Hydroxylactams as Efficient Entries to Diversely Functionalized Ferrociphenols: Synthesis and Antiproliferative Activity Studies. Molecules, 2022, 14, 4549 Angew. Chem. Int. Ed. 2019, 58, 8421-8425.