Catalytic Domino Transformations
Domino Transformations allow the generation of several new bonds in a single synthetic operation, starting from simple substrates. The projects of the team deal with the study of original catalytic enchainements generally involving one or more transition metals.
Pd-Catalyzed Domino Carbonylative-Decarboxylative Allylation : an Easy and Selective Monoallylation of Ketones. In the presence of an allyl alcohol, α-chloroacetophenones undergo an allyloxycarbonylation reaction followed by in situ decarboxylative allylation to selectively afford the corresponding monoallylated ketones via a Pd-catalyzed domino sequence. The scope of the reaction was extended to substituted α-chloroacetophenones as well as various allyl alcohols.